Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo. Comment: some sources erroneously specify "aureothricin" as a synonym of Thiolutin. Aureothricin is an antibiotic very similar to Thiolutin, and is created as a by-product during the Thiolutin fermentation. Oh boy are you kidding? 150 words is the recommended length of entire webpage ! Sturdikova M, Proksa B, Uhrin D, Fuska J. Regulation of biosynthesis of thiolutin and aureothricin in Streptomyces kasugaensis. Folia Microbiol (Praha). 1990;35(4):278-83. Bergmann R. Thiolutin inhibits utilization of glucose and other carbon sources in cells of Escherichia coli. Antonie Van Leeuwenhoek. 1989;55(2):143-52 Jimenez A, Tipper DJ, Davies J. Thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Mode of action. Antimicrob Agents Chemother. 1973 Jun;3(6):729-38. Tipper DJ. Thiolutin inhibits yeast ribonucleic acid polymerases. J Bacteriol. 1973 Oct;116(1):245-56. Ramachandran S, Sukapure RS, Thirumalachar MJ. Bio-transformation of thiolutin production from Streptomyces pimprina to Streptomyces aureofaciens. Hindustan Antibiot Bull. 1965 May;7(4):197-202. Company profile FERMENTEK Ltd. is a young and dynamic company specializing in the research, development and manufacture of biologically active, natural products isolated from microorganisms as well as from other natural sources such as plant and algae. FERMENTEK produces mainly for the research market. Its main customers are universities and other research institutes. The company’s main effort is directed at improving the quality and variety of its products. Quality assurance is regularly adapted to the state of art requirements and today several well-known American companies have selected FERMENTEK as their sole supplier of some specific research biochemicals. FERMENTEK staff consists of microbiologists, chemists and biotechnologists who are constantly screening the research literature for opportunities to develop and manufacture novel and interesting research products. FERMENTEK has been inspected by the IIS (The Standards Institution Of Israel) and found to comply with the Quality Management Standard ISO 9001-2000. Click here to see the certificate record from IIS database. IIS Also certifies that the quality system of Fermentek complies with the Standard Q7A of the FDA (Active Pharmaceutical Ingredients). Click here for that document. Our manufacturing facilities * 360 liter Fermentor * 1500 liter Fermentor * Centrifuges * Evaporators * Laboratories * Quality control Our leading team The Founder, Proprietor and CEO, Yoseph Behrend Research and Development, Maksim Gur Manufacturing, Microbiology, Ephraim Faist Manufacturing, Chemistry, Lior Sinai Manufacturing, Natural products, Silvia Kitman Quality control, Flora Ben-Yizry Sales, Hani (Behrend) Berko Facility engineering, Yehuda Shaanan Maintenance, Riad Awdallah Fermentek Biotechnologies was founded by Dr Yosef Behrend in 1995. Fermentek is located in the Atarot industrial zone in Jerusalem, Israel. Fermentek manufactures bioactive compounds by the means of Fermentation technology. We use Streptomycetes and some other bacteria from soil, Molds (fungi) such as Aspergillus, Penicillium, Fusaria. Several products are derived from plants. Our products are directed for the biological research, in the areas of molecular biology, applied medical research, and, in bulk amounts, for preclinical trials and for drug discovery. We are a manufacturer, not a reseller or a distributor. With few exeptions, all our products are made in house. The majority of our produce is sold to major chemicals trading companies who resell it under their own trade names. The lesser part is sold directly to the end-users who apply to us via the Internet. Among these are university researches, drug discovery companies, and major pharmaceutical manufacturers. All are equally welcome. However, we do not accept one time orders below $500. We are the one of the very few manufacturers of Mycotoxines reference standards. For instance, we are the only ones that make Aflatoxin M2. פרמנטק בע"מ חברת פרמנטק היא חברה ירושלמית צעירה העוסקת בפיתוח וייצור של חמרי טבע בעלי פעילות ביולוגית. החומרים שאנו מייצרים משמשים בתחומים שונים של מחקר ביולוגי. חלק מהמוצרים מיוצרים ברמת GMP/API ומשמשים חומר גלם בתעשיות פרמצבטיות. האחרים משמשים למחקר ביולוגי, רפואי ופרמצבטי. ניתן ליצור קשר עמנו באמצעות דואר אלקטרוני: או טופסCONTACT US טלפון 02-5853953 פקס 02-5853943 מוצרינו נמכרים ללקוחות-קצה בארץ על ידי חברת הולנד-מורן רח גרון 15 יהוד 56217 איש הקשר: ינקי טייטלבום טל 03-5367880, שלוחה 207. One of our competitors, LC laboratories, has published on its website what they call "Fermentek pricelist". We want to clarify that they did neither asked nor recieved our permission to do that, and the prices published there are not correct. As LC labs is neither our subsidiary nor our distributor or agent, we can assume no responsibility whatsoever for their actionפקס 03-5367870